Left temporal perfusion associated with suspiciousness score on the Brief Psychiatric Rating Scale in schizophrenia

Kohno, Tomoya; Shiga, Tohru; Kusumi, Ichiro; Matsuyama, Tetsuaki; Kageyama, Hiroyuki; Katoh, Chietsugu; Koyama, Tsukasa; Tamaki, Nagara

doi:10.1016/j.pscychresns.2006.01.016

« Previous Next »Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 163-171, 30 October 2006

Left temporal perfusion associated with suspiciousness score on the Brief Psychiatric Rating Scale in schizophrenia

Tomoya Kohno
- Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan
- Corresponding author. Tel./fax: +81 11 706 7155.
Tohru Shiga
- Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan
Ichiro Kusumi
- Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Tetsuaki Matsuyama
- Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Hiroyuki Kageyama
- Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan
Chietsugu Katoh
- Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan
Tsukasa Koyama
- Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Nagara Tamaki
- Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan

Received 29 September 2005; received in revised form 25 January 2006; accepted 29 January 2006.

Abstract

We evaluated the relationship between regional cerebral blood flow (rCBF) and clinical symptoms in patients with schizophrenia. Single photon emission computed tomography with N-isopropyl-p-[¹²³I]iodoamphetamine (¹²³I-IMP) was used to study 29 patients with schizophrenia. Clinical symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS). We examined the correlation between rCBF and each BPRS item score using Statistical Parametric Mapping software. Corrected P-values<0.05 were considered as statistically significant. The suspiciousness score on the BPRS was positively correlated with rCBF in the left inferior temporal gyrus. There was no significant correlation between rCBF and any other items of the BPRS. There was no significant correlation between rCBF and chlorpromazine-equivalent dosage. This analysis permits the quantitative assessment of the severity of persecutory delusions in relation to left temporal perfusion in patients with schizophrenia.