Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation

Urrila, Anna S.; Hakkarainen, Antti; Heikkinen, Sami; Huhdankoski, Outi; Kuusi, Tuomo; Stenberg, Dag; Häkkinen, Anna-Maija; Porkka-Heiskanen, Tarja; Lundbom, Nina

doi:10.1016/j.pscychresns.2006.01.010

« Previous Next »Psychiatry Research: Neuroimaging
Volume 147, Issue 1 , Pages 41-46, 30 June 2006

Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation

Anna S. Urrila
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
- Corresponding author. Institute of Biomedicine/Department of Physiology, P.O. Box 63, 00014 University of Helsinki, Helsinki, Finland. Tel.: +358 9 191 25317; fax: +358 9 191 25302.
Antti Hakkarainen
- Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland
Sami Heikkinen
- Laboratory of Organic Chemistry, University of Helsinki, Helsinki, Finland
Outi Huhdankoski
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Tuomo Kuusi
- Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland
Dag Stenberg
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Anna-Maija Häkkinen
- Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Tarja Porkka-Heiskanen
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Nina Lundbom
- Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland

Received 29 October 2005; received in revised form 19 January 2006; accepted 19 January 2006.

Abstract

Proton magnetic resonance spectroscopy (¹H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use ¹H MRS to assess the effects of specific short-term physiological states on major metabolites. Eight healthy women underwent ¹H MRS at the beginning and end of a 40-h period of sleep deprivation. The ratios of N-acetyl-aspartate (NAA), total creatine (tCr), and choline-containing compounds (Cho) to water (H₂O) were determined from the occipital cortex during both baseline and photic stimulation conditions. During sleep deprivation, NAA/H₂O decreased by 7% and Cho/H₂O by 12%. Photic stimulation had no effect on the measured metabolites in the alert state, but in the sleep-deprived state the level of Cho/H₂O increased during neuronal activation. The results suggest that NAA/H₂O and Cho/H₂O may depend on the state of alertness.