Psychiatry Research: Neuroimaging
Volume 148, Issue 2 , Pages 143-149 , 1 December 2006

Volume of cerebellar vermis in monozygotic twins discordant for combat exposure: Lack of relationship to post-traumatic stress disorder

  • James J. Levitt

      Affiliations

    • VA Boston Healthcare System, Clinical Neuroscience Division, Laboratory of Neuroscience, Brockton, MA 02301, United States
    • Psychiatry and Behavioral Science Imaging, Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
    • Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Q. Cece Chen

      Affiliations

    • Massachusetts Institute of Technology, Boston, MA, United States
    • ,
  • Flavia S. May

      Affiliations

    • Psychiatry and Behavioral Science Imaging, Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
    • Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States
    • ,
  • Mark W. Gilbertson

      Affiliations

    • Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • Research Service, VA Medical Center, Manchester, NH, United States
    • ,
  • Martha E. Shenton

      Affiliations

    • VA Boston Healthcare System, Clinical Neuroscience Division, Laboratory of Neuroscience, Brockton, MA 02301, United States
    • Psychiatry and Behavioral Science Imaging, Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
    • Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • ,
  • Roger K. Pitman

      Affiliations

    • Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    • Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States
    • Corresponding Author InformationCorresponding author. MGH-East, Room 2616, Building 149, 13th Street, Charlestown, MA 02129, USA. Tel.: +1 617 726 5333; fax: +1 617 726 4078.

Received 17 September 2004 ,Revised 15 October 2005 ,Accepted 12 January 2006.

References 

  1. Anderson CM, Teicher MH, Polcari A, Renshaw PF. Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood: potential role of the vermis in stress-enhanced risk for drug abuse. Psychoneuroendocrinology. 2002;27:231–244
  2. Bonne O, Gilboa A, Louzoun Y, Brandes D, Yona I, Lester H, et al. Resting regional cerebral perfusion in recent posttraumatic stress disorder. Biological Psychiatry. 2003;54:1077–1086
  3. Courchesne E, Press GA, Murakami J, Berthoty D, Grafe M, Wiley CA, et al. The cerebellum in sagittal plane–anatomic-MR correlation: 1. The vermis. American Journal of Roentgenology. 1989;153:829–835
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  7. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience. 2002;5:1242–1247
  8. Hirayasu Y, McCarley RW, Salisbury DF, Tanaka S, Kwon JS, Frumin M, et al. Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. Archives of General Psychiatry. 2000;57:692–699
  9. Hull AM. Neuroimaging findings in post-traumatic stress disorder: systematic review. British Journal of Psychiatry. 2002;181:102–110
  10. Levitt JJ, McCarley RW, Nestor PG, Petrescu C, Donnino R, Hirayasu Y, et al. Quantitative volumetric MRI study of the cerebellum and vermis in schizophrenia: clinical and cognitive correlates. American Journal of Psychiatry. 1999;156:1105–1107
  11. Little RC, Miliken GA, Stroup WW, Wolfinger RD. SAS System for Mixed Models. Cary, NC: SAS Institute Inc.; 1996;
  12. Orr SP, Metzger LJ, Lasko NB, Macklin ML, Hu FB, Shalev AY, et al. Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with PTSD. Archives of General Psychiatry. 2003;60:283–288
  13. Pissiota A, Frans O, Fernandez M, von Knorring L, Fischer H, Fredrikson M. Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study. European Archives of Psychiatry and Clinical Neuroscience. 2002;2:68–75
  14. Press GA, Murakami J, Courchesne E, Berthoty DP, Grafe M, Wiley CA, et al. The cerebellum in sagittal plane–anatomic-MR correlation: 2. The cerebellar hemispheres. American Journal of Roentgenology. 1989;153:837–846
  15. Reiman EM. The application of positron emission tomography to the study of normal and pathologic emotions. Journal of Clinical Psychiatry. 1997;58S16:4–12
  16. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM. The neurobiological consequences of early stress and childhood maltreatment. Neuroscience and Biobehavioral Reviews. 2003;27:33–44
  17. Weathers FW, Keane TM, Davidson JR. Clinician-administered PTSD scale: a review of the first ten years of research. Depression and Anxiety. 2001;13:132–156
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PII: S0925-4927(06)00015-1

doi: 10.1016/j.pscychresns.2006.01.013

Psychiatry Research: Neuroimaging
Volume 148, Issue 2 , Pages 143-149 , 1 December 2006

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