Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 145-151 , 30 October 2006

Abnormal brain size effect on the thalamus in autism

  • Antonio Y. Hardan

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St., Pittsburgh, PA 15213, United States. Tel.: +1 412 246 6797; fax: +1 412 235 5446.
  • ,
  • Ragy R. Girgis

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, New York, NY, USA
  • ,
  • Jason Adams

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  • ,
  • Andrew R. Gilbert

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  • ,
  • Matcheri S. Keshavan

      Affiliations

    • Department of Psychiatry, Wayne State University, Detroit, MI, USA
  • ,
  • Nancy J. Minshew

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Received 4 August 2005 ,Revised 16 December 2005 ,Accepted 31 December 2005.

References 

  1. Abell F, Krams M, Ashburner J, Passingham R, Friston K, Frackowiak R, et al. The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans. Neuroreport. 1999;10:1647–1651
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Washington, DC: APA; 1994;
  3. Aylward EH, Anderson NB, Bylsma FW, Wagster MV, Barta PE, Sherr M, et al. Frontal lobe volume in patients with Huntington's disease. Neurology. 1998;50:252–258
  4. Aylward EH, Minshew NJ, Field K, Sparks BF, Singh N. Effects of age on brain volume and head circumference in autism. Neurology. 2002;59:175–183
  5. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty P, Mangner T, et al. Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Annals of Neurology. 1997;42:666–669
  6. Cicchetti DV. Multiple comparison methods: establishing guidelines for their valid application in neuropsychological research. Journal of Clinical and Experimental Neuropsychology. 1994;16:55–161
  7. Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, et al. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology. 2001;57:245–254
  8. Creasey H, Rumsey JM, Schwartz M, Duara R, Rapoport JL, Rapoport SI. Brain morphometry in autistic men as measured by volumetric computed tomography. Archives of Neurology. 1986;43:669–672
  9. Daniels DL, Haughton VM, Naidich TP. Cranial and Spinal Magnetic Resonance Imaging: An Atlas and Guide. New York: Raven Press; 1987;
  10. Gilbert AR, Rosenberg DR, Harenski K, Spencer S, Sweeney JA, Keshavan MS. Thalamic volumes in patients with first-episode schizophrenia. American Journal of Psychiatry. 2001;158:618–624
  11. Hall GB, Szechtman H, Nahmias C. Enhanced salience and emotion recognition in autism: a PET study. American Journal of Psychiatry. 2003;160:1439–1441
  12. Hardan AY, Minshew NJ, Mallikarjuhn M, Keshavan MS. Brain volume in autism. Journal of Child Neurology. 2001;16:421–424
  13. Hardan AY, Minshew NJ, Harenski K, Keshavan MS. Posterior fossa magnetic resonance imaging in autism. Journal of the American Academy of Child and Adolescent Psychiatry. 2001;40:666–672
  14. Hardan AY, Kilpatrick M, Keshavan MS, Minshew NJ. Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autism. Journal of Child Neurology. 2003;18:317–324
  15. Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Lange N, Bakardjiev A, et al. Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain. 2003;126:1182–1192
  16. Herrero MT, Barcia C, Navarro JM. Functional anatomy of thalamus and basal ganglia. Child's Nervous System. 2002;18:386–404
  17. Hollingshead AB. Four Factor Index of Social Status. New Haven, CT: Yale University Department of Sociology; 1975;
  18. Horowitz B, Rumsey JM, Grady CL, Rapoport SI. The cerebral metabolic landscape in autism: intercorrelations of regional glucose utilization. Archives of Neurology. 1988;45:749–755
  19. Just MA, Cherkassky VL, Keller TA, Minshew NJ. Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain. 2004;127:1811–1821
  20. Lainhart JE, Piven J, Wzorek M, Landa R, Santangelo SL, Coon H, et al. Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:282–290
  21. Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L, et al. Autism Diagnostic Observation Schedule: a standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders. 1989;19:185–212
  22. Lord C, Rutter M, LeCouteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders. 1994;24:659–685
  23. Luna B, Minshew NJ, Garver KE, Lazar NA, Thulborn KR, Eddy WF, et al. Neocortical system abnormalities in autism: an fMRI study of spatial working memory. Neurology. 2002;59:834–840
  24. Minshew NJ. Autism. In:  Berg BO editors. Principles of Child Neurology. New York: McGraw-Hill; 1996;p. 1713–1730
  25. Minshew NJ. Brief report: brain mechanisms in autism: functional and structural abnormalities. Journal of Autism and Developmental Disorders. 1996;26:205–209
  26. Minshew NJ. What is currently known about the neurobiology of autism and if the valuable resource of family time should be invested in these studies. Journal of Autism and Developmental Disorders. 2004;34:737–738
  27. Minshew NJ, Goldstein G, Siegel DJ. Neuropsychologic functioning in autism: profile of a complex information processing disorder. Journal of the International Neuropsychological Society. 1997;3:303–316
  28. Muller RA, Chugani DC, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, et al. Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography. Neuroscience Letters. 1998;245:1–4
  29. Muller RA, Pierce K, Ambrose JB, Allen G, Courchesne E. Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study. Biological Psychiatry. 2001;49:665–676
  30. Muller RA, Kleinhans N, Kemmotsu N, Pierce K, Courchesne E. Abnormal variability and distribution of functional maps in autism: an fMRI study of visuomotor learning. American Journal of Psychiatry. 2003;160:1847–1862
  31. Pelphrey K, Adolphs R, Morris JP. Neuroanatomical substrates of social cognition dysfunction in autism. Mental Retardation and Developmental Disabilities Research Reviews. 2004;10:259–271
  32. Piven J, Arndt S, Bailey J, Havercamp S, Andreasen NC, Palmer P. An MRI study of brain size in autism. American Journal of Psychiatry. 1995;152:1145–1149
  33. Piven J, Saliba K, Bailey J, Arndt S. An MRI study of autism: the cerebellum revisited. Neurology. 1997;49:546–551
  34. Portas CM, Goldstein JM, Shenton ME, Hokama HH, Wible CG, Fischer I, et al. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biological Psychiatry. 1998;43:649–659
  35. Rasband W. NIH Image Manual. Bethesda, MI: National Institutes of Health; 1997;
  36. Saitoh O, Karns CM, Courchesne E. Development of the hippocampal formation from 2 to 42 years: MRI evidence of smaller area dentata in autism. Brain. 2001;124:1317–1324
  37. Sherman SM, Guillery RW. The role of the thalamus in the flow of information to the cortex. Philosophical Transactions of the Royal Society of London. B, Biological Sciences. 2002;357:1695–1708
  38. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York: Thieme Medical; 1988;
  39. Tsatsanis KD, Rourke BP, Klin A, Volkmar FR, Cicchetti D, Schultz RT. Reduced thalamic volume in high-functioning individuals with autism. Biological Psychiatry. 2003;53:121–129
  40. Waiter GD, Williams JH, Murray AD, Gilchrist A, Perrett DI, Whiten A. A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder. Neuroimage. 2004;22:619–625

PII: S0925-4927(06)00004-7

doi: 10.1016/j.pscychresns.2005.12.009

Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 145-151 , 30 October 2006