Psychiatry Research: Neuroimaging
Volume 146, Issue 2 , Pages 179-184 , 31 March 2006

Cerebral blood flow changes during vagus nerve stimulation for depression

  • Charles R. Conway

      Affiliations

    • Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St. Louis, MO 63104, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 577 8725; fax: +1 314 268 5736.
    • ,
  • Yvette I. Sheline

      Affiliations

    • Washington University School of Medicine, Departments of Psychiatry, Neurology, and Radiology, St. Louis, MO, USA
    • ,
  • John T. Chibnall

      Affiliations

    • Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St. Louis, MO 63104, USA
    • ,
  • Mark S. George

      Affiliations

    • Medical University of South Carolina, Department of Psychiatry, Charleston, SC, USA
    • ,
  • James W. Fletcher

      Affiliations

    • Indiana University School of Medicine, Department of Radiology, Indianapolis, IN, USA
    • ,
  • Mark A. Mintun

      Affiliations

    • Washington University School of Medicine, Departments of Psychiatry and Radiology, St. Louis, MO, USA

Received 19 July 2005 ,Revised 15 November 2005 ,Accepted 5 December 2005.

References 

  1. Bohning DE, Lomarev MP, Denslow S, Nahas Z, Shastri A, George MS. Feasibility of vagus nerve stimulation-synchronized blood oxygenation level-dependent functional MRI. Investigative Radiology. 2001;36:470–479
  2. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME. A functional anatomy study of unipolar depression. Journal of Neuroscience. 1992;12:3628–3641
  3. Garnett ES, Nahmias C, Scheffel A, Firnau G, Upton AR. Regional cerebral blood flow in man manipulated by direct vagal nerve stimulation. Pacing and Clinical Electrophysiology. 1992;15:1579–1580
  4. Henry TR. Therapeutic mechanism of vagus nerve stimulation. Neurology. 2002;59(Suppl 4):S3–S14
  5. Henry TR, Bakay RA, Votaw JR, Pennell PB, Epstein CM, Faber TL, et al. Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy. I. Acute effects at high and low levels of stimulation. Epilepsia. 1998;39:983–990
  6. Henry TR, Votaw JR, Pennell PB, Epstein CM, Bakay RA, Faber TL, et al. Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy. Neurology. 1999;52:1166–1173
  7. Henry TR, Bakay RA, Pennell PB, Epstein CM, Votaw JR. Brain blood-flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy. II. Prolonged effects at high and low levels of stimulation. Epilepsia. 2004;45:1064–1070
  8. Lomarev M, Denslow S, Nahas Z, Chae JH, George MS, Bohning DE. Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects. Journal of Psychiatric Research. 2002;36:219–227
  9. Mayberg HS. Positron emission tomography imaging in depression: a neural systems perspective. Neuroimaging Clinics of North America. 2003;13:805–815
  10. Mayberg HS, Lewis PJ, Regenold W, Wagner HN. Paralimbic hypoperfusion in unipolar depression. Journal of Nuclear Medicine. 1994;35:929–934
  11. Snyder AZ. Difference image versus ratio image error functions in PET realignment. In:  Myer R,  Cunningham VJ,  Bailey DL,  Jones T editor. Quantification of Brain Function Using PET. San Diego, CA: Academic Press; 1996;p. 131–137
  12. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York: Thieme; 1988;
  13. Woods RP, Cherry SR, Mazziotta JC. Rapid automated algorithm for aligning and reslicing PET images. Journal of Computer Assisted Tomography. 1992;16:620–633
  14. Woods RP, Grafton ST, Watson JD, Sicotte NL, Mazziotta JC. Automated image registration. II. Intersubject validation of linear and nonlinear models. Journal of Computer Assisted Tomography. 1998;22:153–165
  15. Zobel A, Joe A, Freymann N, Clusmann H, Schramm J, Reinhardt M, et al. Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: an exploratory approach. Psychiatry Research: Neuroimaging. 2005;139:165–179

PII: S0925-4927(05)00207-6

doi: 10.1016/j.pscychresns.2005.12.007

Psychiatry Research: Neuroimaging
Volume 146, Issue 2 , Pages 179-184 , 31 March 2006

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