MRI study of corpus callosum in children and adolescents with bipolar disorder

Yasar, A. Sibel; Monkul, E. Serap; Sassi, Roberto B.; Axelson, David; Brambilla, Paolo; Nicoletti, Mark A.; Hatch, John P.; Keshavan, Matcheri; Ryan, Neal; Birmaher, Boris; Soares, Jair C.

doi:10.1016/j.pscychresns.2005.09.004

« Previous Next »Psychiatry Research: Neuroimaging
Volume 146, Issue 1 , Pages 83-85, 30 January 2006

MRI study of corpus callosum in children and adolescents with bipolar disorder

A. Sibel Yasar
- MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7792, San Antonio, TX, 78229-3900, USA
E. Serap Monkul
- MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7792, San Antonio, TX, 78229-3900, USA
Roberto B. Sassi
- Department of Psychiatry, Institute of Psychiatry, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
David Axelson
- Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Paolo Brambilla
- Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Verona, Italy
Mark A. Nicoletti
- MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7792, San Antonio, TX, 78229-3900, USA
John P. Hatch
- MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7792, San Antonio, TX, 78229-3900, USA
Matcheri Keshavan
- Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Neal Ryan
- Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Boris Birmaher
- Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Jair C. Soares
- MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7792, San Antonio, TX, 78229-3900, USA
- South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA
- Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
- Corresponding author. MOOD-CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7792, San Antonio, TX, 78229-3900, USA. Tel.: +1 210 562 5487; fax: +1 210 562 5485.

Received 23 September 2004; received in revised form 25 August 2005; accepted 27 September 2005.

Abstract

This structural magnetic resonance imaging study examined the length, areas, and circularity of the corpus callosum (CC) in 16 children and adolescents with bipolar disorder and 21 healthy controls. Bipolar disorder patients had lower circularity of the CC splenium compared with healthy controls. No significant differences in CC length or area were observed, suggesting that reported CC abnormalities appear late in the course of bipolar disorder.

Keywords: Mood disorders, Neuroimaging, White matter