Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 269-273, 30 August 2005

Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis

  • Nikolaus Michael

      Affiliations

    • Department of Psychiatry, University of Münster, Albert-Schweitzer-Straβe 11, 48129 Münster, Germany
    • ,
  • Andreas Erfurth

      Affiliations

    • Department of Psychiatry, University of Münster, Albert-Schweitzer-Straβe 11, 48129 Münster, Germany
    • ,
  • Peter Lüdemann

      Affiliations

    • Department of Neurology, University of Münster, Albert-Schweitzer-Straβe 33, 48129 Münster, Germany
    • ,
  • Gerhard Schuierer

      Affiliations

    • Institute of Neuroradiology, University of Regensburg, District Medical Center, Universitätsstraβe 84, 93053 Regensburg, Germany
    • ,
  • Harald E. Möller

      Affiliations

    • Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraβe 1a, D-04103 Leipzig, Germany
    • Department of Radiology, University of Münster, Albert-Schweitzer-Straße 33, 48129 Münster, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 341 9940 212; fax: +49 341 9940 221.

Received 28 August 2003; received in revised form 22 December 2004; accepted 5 January 2005.

Abstract 

A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy. Metabolic abnormalities included decreased N-acetylaspartate and elevated choline and myo-inositol in a lesion visible on magnetic resonance imaging and in normal-appearing white matter. Lactate appeared increased within the lesion. Metabolic impairment was persistent after intrathecal interferon-α treatment. Spectroscopy pointing to ongoing inflammation, gliosis, and possible membrane turnover was more sensitive than imaging in detecting widespread pathology within the white matter.

Keywords: Electroconvulsive therapy, Interferon-α, Proton magnetic resonance spectroscopy, Psychosis, Subacute sclerosing panencephalitis

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PII: S0925-4927(05)00073-9

doi:10.1016/j.pscychresns.2005.01.003

Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 269-273, 30 August 2005

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