Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 239-247 , 30 August 2005

Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia

  • Jung-Seok Choi

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • Do-Hyung Kang

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • Jae-Jin Kim

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • BK 21 Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Tae-Hyun Ha

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • Kyu Sik Roh

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • Tak Youn

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • BK 21 Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Jun Soo Kwon

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • BK 21 Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author. Department of Psychiatry and Nuclear Medicine, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea. Tel.: +82 2 2072 2972; fax: +82 2 747 9063.

Received 6 May 2003 ,Revised 27 May 2004 ,Accepted 27 May 2004.

References 

  1. Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P. The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Annals of the New York Academy of Sciences. 2001;935:107–117
  2. American Psychiatric Association. DSM-IV. Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: APA; 1994;
  3. Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze V, O'Leary DS, et al. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. Journal of the American Medical Association. 1994;272:1763–1769
  4. Benes FM. Neurobiological investigations in cingulate cortex of schizophrenic brain. Schizophrenia Bulletin. 1993;19:537–549
  5. Bensaid AM, Hall LO, Bezdek JC, Clarke LP. Partially supervised clustering for image segmentation. Pattern Recognition. 1996;29:859–871
  6. Buchsbaum MS, Someya T, Teng CY, Abel L, Chin S, Najafi A, et al. PET and MRI of the thalamus in never-medicated patients with schizophrenia. American Journal of Psychiatry. 1996;153:191–199
  7. Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL. The counting Stroop: an interference task specialized for functional neuroimaging—validation study with functional MRI. Human Brain Mapping. 1998;6:270–282
  8. Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA, et al. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biological Psychiatry. 1999;45:1542–1552
  9. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences. 2000;4:215–222
  10. Byne W, Buchsbaum MS, Kemether E, Hazlett EA, Shinwari A, Mitropoulou V, et al. Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder. Archives of General Psychiatry. 2001;58:133–140
  11. Cannon M, Dave J, Bezdek J. Efficient implementation of the fuzzy C-means clustering algorithm. IEEE Transactions on Pattern Analysis and Machine Intelligence. 1986;8:248–255
  12. Cleghorn JM, Garnett ES, Nahmias C, Brown GM, Kaplan RD, Szechtman H, et al. Regional brain metabolism during auditory hallucinations in chronic schizophrenia. British Journal of Psychiatry. 1990;157:562–570
  13. Crespo-Facorro B, Kim JJ, Andreasen NC, O'Leary DS, Wiser AK, Bailey JM, et al. Human frontal cortex: an MRI-based parcellation method. NeuroImage. 1999;10:500–519
  14. Crespo-Facorro B, Kim JJ, Andreasen NC, O'Leary DS, Magnotta V. Regional frontal abnormalities in schizophrenia: a quantitative gray matter volume and cortical surface size study. Biological Psychiatry. 2000;48:110–119
  15. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain. 1995;118(Pt. 1):279–306
  16. Drevets WC, Ongur D, Price JL. Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders. Molecular Psychiatry. 1998;3(220–226):190–191
  17. Duncan J, Owen AM. Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends in Neurosciences. 2000;23:475–483
  18. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID), Clinician Version: Administration Booklet. Washington, DC: American Psychiatric Press; 1996;
  19. Flaum M, Swayze VW, O'Leary DS, Yuh WT, Ehrhardt JC, Arndt SV, et al. Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. American Journal of Psychiatry. 1995;152:704–714
  20. Funahashi S. Neuronal mechanisms of executive control by the prefrontal cortex. Neuroscience Research. 2001;39:147–165
  21. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome?. Clinical Neuroscience. 1995;3:89–97
  22. Graybiel AM. The basal ganglia and cognitive pattern generators. Schizophrenia Bulletin. 1997;23:459–469
  23. Gur RE, Maany V, Mozley PD, Swanson C, Bilker W, Gur RC. Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. American Journal of Psychiatry. 1998;155:1711–1717
  24. Gur RE, Cowell PE, Latshaw AB, Turetsky BI, Grossman RI, Arnold SE, et al. Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Archives of General Psychiatry. 2000;57:761–768
  25. Haznedar MM, Buchsbaum MS, Luu C, Hazlett EA, Siegel BV, Lohr J, et al. Decreased anterior cingulate gyrus metabolic rate in schizophrenia. American Journal of Psychiatry. 1997;154:682–684
  26. Hoffman RE, McGlashan TH. Reduced corticocortical connectivity can induce speech perception pathology and hallucinated ‘voices’. Schizophrenia Research. 1998;30:137–141
  27. Hollingshead AB, Redlich FC. Social Class and Mental Illness: A Community Study. New York: John Wiley and Sons; 1958;
  28. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  29. Keshavan MS, Rosenberg D, Sweeney JA, Pettegrew JW. Decreased caudate volume in neuroleptic-naive psychotic patients. American Journal of Psychiatry. 1998;155:774–778
  30. Kircher TT, Liddle PF, Brammer MJ, Williams SC, Murray RM, McGuire PK. Neural correlates of formal thought disorder in schizophrenia: preliminary findings from a functional magnetic resonance imaging study. Archives of General Psychiatry. 2001;58:769–774
  31. Koski L, Paus T. Functional connectivity of the anterior cingulate cortex within the human frontal lobe: a brain-mapping meta-analysis. Experimental Brain Research. 2000;133:55–65
  32. Kwon JS, McCarley RW, Hirayasu Y, Anderson JE, Fischer IA, Kikinis R, et al. Left planum temporale volume reduction in schizophrenia. Archives of General Psychiatry. 1999;56:142–148
  33. Menon V, Anagnoson RT, Mathalon DH, Glover GH, Pfefferbaum A. Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms. NeuroImage. 2001;13:433–446
  34. Noga JT, Aylward E, Barta PE, Pearlson GD. Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Research: Neuroimaging. 1995;61:201–208
  35. Pakkenberg B. Post-mortem study of chronic schizophrenic brains. British Journal of Psychiatry. 1987;151:744–752
  36. Picard N, Strick PL. Motor areas of the medial wall: a review of their location and functional activation. Cerebral Cortex. 1996;6:342–353
  37. Portas CM, Goldstein JM, Shenton ME, Hokama HH, Wible CG, Fischer I. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biological Psychiatry. 1998;43:649–659
  38. Posner MI, Rothbart MK. Attention, self-regulation and consciousness. Philosophical Transactions: Biological Sciences. 1998;353:1915–1927
  39. Sabri O, Erkwoh R, Schreckenberger M, Owega A, Sass H, Buell U. Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics. Lancet. 1997;349:1735–1739
  40. Silbersweig DA, Stern E, Frith C, Cahill C, Holmes A, Grootoonk S, et al. A functional neuroanatomy of hallucinations in schizophrenia. Nature. 1995;378:176–179
  41. Szeszko PR, Bilder RM, Lencz T, Pollack S, Alvir JMJ, Ashtari M, et al. Investigation of frontal lobe subregions in first-episode schizophrenia. Psychiatry Research: Neuroimaging. 1999;90:1–15
  42. Takahashi T, Kawasaki Y, Kurokawa K, Hagino H, Nohara S, Yamashita I, et al. Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study. Schizophrenia Research. 2002;55:69–81
  43. Tamminga CA, Vogel M, Gao X, Lahti AC, Holcomb HH. The limbic cortex in schizophrenia: focus on the anterior cingulate. Brain Research Reviews. 2000;31:364–370
  44. Tekin S, Cummings J. Frontal-subcortical neuronal circuits and clinical neuropsychiatry. An update. Journal of Psychosomatic Research. 2002;53:647–654
  45. Vogt BA, Pandya DN, Rosene DL. Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents. Journal of Comparative Neurology. 1987;262:256–270
  46. Vogt BA, Finch DM, Olson CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cerebral Cortex. 1992;2:435–443
  47. Whalen PJ, Bush G, McNally RJ, Wilhelm S, McInerney SC, Jenike MA, et al. The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division. Biological Psychiatry. 1998;44:1219–1228

PII: S0925-4927(05)00068-5

doi: 10.1016/j.pscychresns.2004.05.008

Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 239-247 , 30 August 2005

Article Tools

* Image Usage & Resolution