Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 263-267, 30 August 2005

Left frontotemporal hyperperfusion in a patient with post-stroke mania

  • Masaru Mimura

      Affiliations

    • Department of Neuropsychiatry, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 3784 8569; fax: +81 3 3784 8354.
    • ,
  • Kazuyuki Nakagome

      Affiliations

    • Department of Neuropsychiatry, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
    • ,
  • Natsuko Hirashima

      Affiliations

    • Department of Neuropsychiatry, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
    • ,
  • Hiroshi Ishiwata

      Affiliations

    • Department of Neuropsychiatry, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
    • ,
  • Kunitoshi Kamijima

      Affiliations

    • Department of Neuropsychiatry, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
    • ,
  • Akira Shinozuka

      Affiliations

    • Department of Radiology, Showa University School of Medicine, Tokyo, Japan
    • ,
  • Hiroshi Matsuda

      Affiliations

    • Department of Nuclear Medicine, Saitama Medical School Hospital, Saitama, Japan

Received 28 September 2004; received in revised form 13 April 2005; accepted 8 May 2005.

Abstract 

A 78-year-old housewife with major depression developed a right-sided infarction in the territory of the middle cerebral arteries, followed by acute post-stroke mania. Comparison between pre- and post-stroke SPECT scans demonstrated a unique pattern of left orbitofrontal hyperperfusion with extensive right frontal hypoperfusion. A functional imbalance between right and left orbitofrontal cortices may be important in mania.

Keywords: Orbitofrontal cortex, Single photon emission tomography, Mood disorder

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PII: S0925-4927(05)00065-X

doi:10.1016/j.pscychresns.2005.05.007

Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 263-267, 30 August 2005

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