Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 239-247, 30 August 2005

Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia

  • Jung-Seok Choi

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
  • ,
  • Do-Hyung Kang

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
  • ,
  • Jae-Jin Kim

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • BK 21 Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Tae-Hyun Ha

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
  • ,
  • Kyu Sik Roh

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
  • ,
  • Tak Youn

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • BK 21 Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Jun Soo Kwon

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    • BK 21 Human Life Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author. Department of Psychiatry and Nuclear Medicine, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea. Tel.: +82 2 2072 2972; fax: +82 2 747 9063.

Received 6 May 2003; received in revised form 27 May 2004; accepted 27 May 2004.

Abstract 

The anterior cingulate gyrus is a heterogeneous region that has specialized subdivisions with respect to its cytoarchitecture, function and connectivity. The aim of this study was to examine the morphological changes of the caudal subdivision of the anterior cingulate gyrus in the context of the cortico-striatal-thalamo-cortical circuitry of schizophrenia and their relationship to clinical symptoms. Accordingly, we measured the volumes of the caudal and rostral anterior cingulate gyrus, the orbitofrontal cortex, the caudate and the thalamus by magnetic resonance imaging in age- and sex-matched groups, which consisted of 22 patients with schizophrenia and 22 normal volunteers. The clinical symptoms of schizophrenia patients were obtained using the Positive and Negative Syndrome Scale. Volumetric reduction of the right caudal anterior cingulate gyrus was observed in patients with schizophrenia as compared with the normal controls. Furthermore, a smaller volume of the caudal anterior cingulate gyrus was significantly correlated with more severe positive symptoms of schizophrenia. Thus, these findings suggest that a volumetric abnormality of the caudal anterior cingulate gyrus in schizophrenia may be related to positive symptoms and possibly involved in the pathophysiology of schizophrenia.

Keywords: Schizophrenia, MRI, Caudal anterior cingulate gyrus, Psychopathology

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PII: S0925-4927(05)00068-5

doi:10.1016/j.pscychresns.2004.05.008

Psychiatry Research: Neuroimaging
Volume 139, Issue 3 , Pages 239-247, 30 August 2005